UPTAKE AND DISTRIBUTION OF VOLATILE ANESTHETICS

UPTAKE AND DISTRIBUTION OF VOLATILE ANESTHETICS

• Vessel-rich organs: brain, heart, liver, kidneys, endocrine system; 10% of the body weight; receive 75% of the cardiac output ; small volume; moderate solubility; rapid saturation

• Muscle group : 50% of body weight; receives 20% of the cardiac output; continued uptake as a result of greater volume ; uptake can last for hours

• Fat group : 20% of total body weight; receives 6% of cardiac output; high solubility for anesthetic agent so can have sustained uptake for days

• Vessel-poor group : 20% of body weight; minimal cardiac output; uptake is insignifi cant