Anesthesiology and Intensive Care

Epinephrine (Adrenaline)  is naturally occurring catecholamine. It is is the prototype sympathomimetic . Epinephrine is synthesized, stored, and released from the adrenal medulla. Through activation of a-adrenergic receptors , b1 and b2 receptors regulates: myocardial contractility heart rate vascular and bronchial smooth muscle tone glandular secretions metabolic processes such as glycogenolysis and lipolysis Not administered orally as it is rapidly metabolized in the gastrointestinal mucosa and liver. Therefore, epinephrine is administered subcutaneously,  intramuscularly  (Epipen), or   intravenously . Indications allergic reactions/ anaphylaxis treatment of severe asthma and bronchospasm during cardiopulmonary resuscitation during periods of hemodynamic instability to enhance myocardial contractility and increase vascular resistance during weaning from cardiopulmonary bypass increasing cardiac output in sepsis as part of local anesthetic solutions  ...

1. Eliminate any allergy triggers 2. Get ready for intubation as edema can progress shortly. 3. Provide oxygen flow. 4. Provide reliable intravenous access with large bore cannula. 5. Give 20-30 mL/kg crystalloid iv.

    Adrenaline (Epinephrine) in anaphylaxis case keywords:  Adrenaline in anaphylaxis, Epinephrine for anaphylaxis, Anaphylactic shock treatment, Adrenaline injection, Epinephrine auto-injector, Anaphylaxis emergency, Adrenaline dosage As an alpha-receptor agonist, it reverses peripheral vasodilation and reduces oedema.  Its beta-receptor  activity dilates the bronchial airways, increases the force of myocardial contraction, and suppresses histamine and leukotriene release.  There are also beta-2 adrenergic receptors on mast cells that inhibit activation, and so early adrenaline attenuates the severity of IgE-mediated allergic reactions.