Prolonged QT: Causes & Drugs

Drugs whose administration risks converting aprolonged QTc 
to Torsades de pointes, including:


The QT interval is measured from the start of the Q wave till the end of the T wave.
The corrected QT interval is calculated using Bazett’s formula:
QTc = (QT interval ) / √(RR Interval)


A QTc of > 440 msec is considered prolonged.


Causes:

Medications (more than 75) that can lengthen the QT interval and upset heart rhythm include:
  • Certain antibiotics
  • Certain antidepressant and antipsychotic medications
  • Some antihistamines
  • Diuretics
  • Medications used to maintain normal heart rhythms (antiarrhythmic medications)
  • Cholesterol-lowering medications
  • Certain diabetes medications


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