Patients at Risk for Adverse Events During Nonsteroidal Antiinflammatory Drug (NSAID) Therapy

1. Patients with dehydration, hypovolemia or who have impaired renal function are at increased risk for decreasing renal function or renal failure.


2. Patients with liver disease or congestive heart failure—in particular, those already taking ACE inhibitors, ARBs, or diuretics—in whom liver or heart conditions may worsen.

3. Older patients are at enhanced risk for GI and renal events.

4. Patients with asthma and known aspirin hypersensitivity are increased risk of bronchospasm.

5. Women in the third trimester of pregnancy—NSAIDs may prolong gestation or prematurely close the ductus arteriosus.

6. Patients who use tobacco or ethanol with a history of gastritis or peptic ulcer disease are at increased risk for peptic ulcer or GI bleed.