Anesthesiology and Intensive Care

Perioperative Pain Management

Mechanism of action:  Mechanism of action of pregabalin has not been exactly  explained. It  binds with high affinity to the alpha2-delta site -  subunit of voltage-dependent calcium channels  in central nervous system.Thus, calcium currents decrease, which may be associated with the antinociceptive and antiseizure effects of pregabalin.  Nociception   is the recognizing of painful stimuli.

Drugs for Cesarean Delivery & Duration of Surgical Anesthesia:

              Pain is often the patient’s presenting symptom.  It can provide useful clinical information and it is your responsibility to use this information to help the patient and alleviate suffering.     Manage pain wherever you see patients (emergency, operating room and on the ward) and anticipate their needs for pain management after surgery and discharge.  Do not unnecessarily delay the treatment of pain; for example, do not transport a patient without analgesia simply so that the next practitioner can appreciate how much pain the patient is experiencing.